Proton Pump Inhibitors PPIs

What We have Discovered Regarding PPI or Proton Pump Inhibitors

These Acid Reducing medications substantially reduce the Parietal, acid producing, cells’ ability to produce sufficiently strong acid and are derivative of the drug Prazole. There are two types: Reversible and Irreversible. The irreversible Proton Pump Inhibitor causes extreme acid suppression of the acid producing cells and sometimes leads to Achlorhydria, typhoid, cholera and dysentery. This is because gastric juice (HCL) plays a major role in killing microbes present in the foods consumed. Significant drug interaction can lead to decreased absorption of some vitamins, minerals, and supplements. This is especially true with vitamin B-12, Iron salts, etc. It is also responsible for astrinemia, gastric polyps and carcinoma. There is no sterilization of the nutrients consumed, no conversion of the proteins into Peptones, and decreased Amino acid integrity. Use of these products can have serious side effects, a few of the side effects as follows: Allergies, Bacterial, and Fungal proliferation, osteoporosis, diarrhea and or constipation, nausea, abdominal pain, decreased immune system response, etc. Long-term use of these PPIs has been reported to be associated with acute interstitial nephritis progressing to acute renal failure.
PPIs eliminate the Proton pump from the digestive process. In young adults the renewal of activity of pumping (producing hydrochloric acid) requires the synthesis of a new proton pump. The half-life for the renewal of the pump is 18 to 24 hours; a single intake of the products allows an inhibition of almost 24 hours. As a person ages the renewal time for synthesis of a new proton pump increases. In some case older patients take substantially longer to renew the proton pump, if at all.

The following is a list of a few of the Proton Pump Inhibitors:

  • Omeprazole
  • Prilosec Lansoprazole
  • Prevacid Pantoprazole
  • Protonix Rabeprazole
  • Acidphex Esomeprazole
  • Nexium