Anemia and Digestion

Pernicious Anemia is a form of Megaloblastic Anemia due to Vitamin B-12 deficiency. Impaired absorption of Vitamin B-12 is common in the setting of Atrophic Gastritis, and is increased when the stomachs Parietal Cells cease production of Hydrochloric acid (HCL). In addition to producing the HCL, the Parietal Cells also produce the intrinsic factor, a glycoprotein, necessary for the absorption of Vitamin B-12 in the small bowel. Pernicious Anemia resembles that of any other form of Anemia, but is often accompanied by manifestations of Vitamin B-12 deficiency (notably neurological abnormalities such a peripheral neuropathy), as well as by other manifestation of autoimmune atrophic Gastritis. Most commonly, the cause for impaired binding of Vitamin B-12 by the Intrinsic Factor is autoimmune Atrophic Gastritis, in which Autoantibodies are directed against the stomachs Parietal Cells (resulting in their loss) as well as against the Intrinsic Factor itself (rendering it unable to bind Vitamin B-12 in the small bowel). Less frequently, loss of the stomachs Parietal Cells may simply be part of a widespread Atrophic Gastritis of non-autoimmune origin, such as that frequently occurring in elderly people affected with long-standing chronic Gastritis of any cause (including Helicobacter Pylori infection). H. Pylori infections will stop the acid producing Parietal cells from producing acid.
Gastric Parietal Cell Antibodies are present in 95% of Patients with Pernicious Anemia and up to 30% in Iron Deficiency Anemia. These antibodies are also found in association with Thyroid Disease. The occurrence of the Gastric Parietal Cell Antibodies increases with the aging process. This condition results in the complete loss of the First Stage of Digestion. Un-converted Protein, which contains Allergens, is passed through the stomach, without the benefit of sterilization, Peptic conversion, or emulsification, creating numerous Allergies, and other ailments. Pernicious Anemia results in Achlorhydria, the complete loss of HCL production and Pepsin in the stomach. The Immune System has little or no support. Achlorhydria and Pernicious Anemia is most prevalent in the latter stages of HIV